The antioxidant benefits of curcumin-pepper combination for diabetic


Diabetes is a chronic metabolic condition wherein blood sugar levels in the body remain high as the body fails to regulate it. Insulin is the hormone that plays a vital role in this disease. It is produced by the pancreas and it controls the blood sugar. Blood sugar or glucose acts as a fuel for various cellular activities. Insulin moves glucose from blood to muscles, fat and liver cells where it is stored or used as fuel.

Insulin in diabetes

In diabetes either little insulin or insulin resistance hampers this transformation of glucose and in turn tends to affect the body negatively. Type 2 diabetes is a form of diabetes caused due to failure of cells to respond to insulin appropriately. Type 2 can be cured by use of medications with or without insulin and lifestyle changes.

Oxidative stress in diabetes

Oxidative stress plays a major role in pathogenesis of diabetes. Oxidative stress is the loss of balance between body’s natural antioxidant defenses and production of reactive oxygen species. Oxidative stress is known to play a role in the development of type 2 diabetes, and conditions related to elevated blood sugar (hyperglycemia) may also contribute to oxidative stress.

The benefits of turmeric with oxidative stress in diabetes

Turmeric, a known antioxidant, scavenges ROS (reactive oxygen species), inhibits lipid peroxidation and increases the levels of antioxidant enzymes . This property of turmeric can help reduce oxidative stress observed in diabetes.Study in humans shows that curcumin, a component of turmeric, works as an antioxidant and reduces oxidative stress and heart risk in diabetes. Supplements formulated with Curcumin and BioPerine reduce oxidative stress in patients suffering from type 2 diabetes. Curcumin supplements are found to raise the level of antioxidant enzymes in diabetes.

Curcumin-pepper combination for oxidative stress

The results of the study indicated that curcumin supplements, at a dose of 1000 mg/day for a period of 3 months can significantly decrease serum MDA (a marker of oxidative stress) and increase TAC (serum total antioxidant capacity) and SOD (an antioxidant enzyme) activities in patents with diabetes, as researches demonstrated. What does this mean? It means that curcuminoids found in turmeric are natural antioxidants that help improve antioxidant defense in diabetes.

The study showed that clinical use of curcuminoids has been alleged to be limited by low oral bioavailability owing to the rapid intestinal and hepatic metabolism of these compounds. To tackle this limitation, curcuminoids were co-administered with piperine in this study. The efficacy and safety of such a combination has been shown in several previous trials. Commenting on the study’s findings, Nagabhushanam Kalyanam, PhD, said: ”The growing body of science indicates this combination can play a significant role in supporting the health of diabetes patients, and we intend to pursue this line of study further”.

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